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Whole Exome Sequencing: A Strategic, Cost-Effective, and High-Throughput Genomic Tool for Rapidly Identifying Causal Coding Variants in Inherited Rare Diseases, Undiagnosed Disorders, and Cancer Research

Whole Exome Sequencing (WES) is a widely adopted Next-Generation Sequencing (NGS) technique that focuses on sequencing the protein-coding regions of the genome, known as the exome, which constitutes less than 2% of the total genetic material but harbors approximately 85% of known disease-causing mutations. By focusing only on these functional regions, WES offers a more cost-effective and streamlined approach than whole-genome sequencing (WGS), making it particularly valuable in clinical diagnostics and for the rapid identification of de novo or rare variants linked to Mendelian and complex diseases.

The recent sports day organized by our school was a wonderful experience for me. The event was full of variety, including tug-of-war, football matches, dance performances, and even cooking activities. During the tug-of-war, I deeply felt the power of teamwork as everyone pulled together while the cheers echoed around us. On the football field, students showed great energy and fighting spirit, which was truly inspiring. The dance performances brought joy and creativity, adding a lively and cheerful atmosphere to the day. What impressed me most was the dumpling-making and food-sharing session. Although we come from different countries and regions, we worked together to make delicious food and shared our cultures, which gave me a warm feeling of home. Through this event, I not only exercised my body but also made new friends and experienced the value of community. This will remain a beautiful memory during my study in Thailand.

学校举办的运动会让我收获颇多。活动内容非常丰富，不仅有拔河、踢足球等竞技比赛，还有舞蹈表演和美食环节。拔河比赛时，同学们齐心协力，大家的加油声此起彼伏，让我深切感受到团队合作的力量。足球比赛中，同学们拼尽全力，展现了青春的活力与拼搏的精神。舞蹈表演则充满了欢乐与创意，给现场增添了轻松愉快的氛围。让我印象最深的是包饺子和美食分享环节，大家来自不同国家和地区，却能一起动手做美食，互相交流，这让我感受到了家的温暖。通过这次活动，我不仅锻炼了身体，也收获了友谊，更体会到了集体活动的意义。这段经历将成为我在泰国求学期间一段美好的回忆。

在泰国

东硕学院参加了人生中第一次国外的拜师节，真的太特别啦！仪式超庄重——学生们献上花束，老师为我们系上祝福的绳结，满满的仪式感，让我第一次这么直观地感受到泰国“尊师重道”的文化。

仪式结束后我们还一起包饺子，在各国同学面前展示中国味道。中式的家乡味道遇上异国氛围，别提多有意思了！

国际友人在雨中进行各项活动展现了他们的体育精神。

特别感谢各位老师和同学们的用心，让我们在异国他乡也能感受到温暖与归属感。这段经历很难忘的。

I attended my first overseas Teachers' Day at thongsook College in Thailand. It was truly special! The ceremony was incredibly solemn—students presented bouquets of flowers, and teachers tied knots of blessings for us. It was a truly ceremonial experience, and for the first time, I experienced firsthand the Thai culture of respecting teachers.

Through the Teacher's Day, we experienced the differences between Thai and Chinese cultural customs. Students meticulously wove bouquets for their teachers, while teachers tied strings to bless the students. Teacher's Day is not only a tribute to the hard work of teachers but also embodies the spirit of respecting teachers and valuing the way. Students from various countries also engaged in friendly interactions.

9月14日，周日，东硕学院举行了迎新生，拜师礼活动，世界各地学生身穿东硕校服，手捧鲜花敬献给老师们，以表尊敬和感恩。拜师礼从不是终点，而是一份「以心传心」的约定：往后在这里学习的日子里，我会带着老师们给于的勇气继续走，也会把这份「尊重」与「传承」，传递给更多需要的人。师者，传道授业解惑也。

中午，中国学生在厨房烹饪具由中国各色的美食：饺子、酸辣土豆丝、红烧肉、可乐鸡翅、番茄炒蛋等，并邀请全校师生品尝，通过美食分享中国传统文化，同时促进全校师生之间的交流，共赴一场“舌尖上的中国”约会。

On Sunday, September 14th, the Thongsook College held a welcome ceremony for new students and a teacher homage event. Students from all over the world wore the Thongsook College uniforms and presented flowers to their teachers as a token of respect and gratitude. The teacher homage ceremony is not an end point, but a promise of "passing on the heart": in the days of studying here, I will continue to walk with the courage given by the teachers, and I will pass on this "respect" and "inheritance" to more people who need it. Teachers impart knowledge and answer questions.

At noon, Chinese students were cooking a variety of Chinese dishes in the kitchen: dumplings, spicy shredded potatoes, Braised pork belly, Coca-Cola chicken wings, Stir-fried tomato and scrambled eggs, etc., and invited all teachers and students to taste them. Through sharing Chinese traditional culture through food, they also promoted…

Participating in the school's Teacher's Day celebration was a truly meaningful experience. It was heartwarming to see students and teachers come together to express gratitude and respect. The performances, speeches, and small gifts all carried sincere emotions. I realized how much our teachers dedicate themselves to guiding and supporting us. This event not only strengthened the bond between students and teachers but also inspired me to study harder and appreciate their efforts more. I feel fortunate to be part of such a caring school community.